---
product_id: 368651743
title: "SAM-e 400mg 30 Enteric Coated Caplets. Vegan, Kosher, Non-GMO, Soy Free, Gluten Free - Mood and Joint Support - Cold Form Blister Packed."
brand: "natures trove"
price: "B/.116"
currency: PAB
in_stock: false
reviews_count: 5
category: "Natures Trove"
url: https://www.desertcart.com.pa/products/368651743-sam-e-400mg-30-enteric-coated-caplets-vegan-kosher-non
store_origin: PA
region: Panama
---

# Vegan, Non-GMO, Gluten & Soy free 400mg potent dose Enteric coated for max absorption SAM-e 400mg 30 Enteric Coated Caplets. Vegan, Kosher, Non-GMO, Soy Free, Gluten Free - Mood and Joint Support - Cold Form Blister Packed.

**Brand:** natures trove
**Price:** B/.116
**Availability:** ❌ Out of Stock

## Summary

> 🌟 Elevate your mood & mobility with science-backed SAM-e power!

## Quick Answers

- **What is this?** SAM-e 400mg 30 Enteric Coated Caplets. Vegan, Kosher, Non-GMO, Soy Free, Gluten Free - Mood and Joint Support - Cold Form Blister Packed. by natures trove
- **How much does it cost?** B/.116 with free shipping
- **Is it available?** Currently out of stock
- **Where can I buy it?** [www.desertcart.com.pa](https://www.desertcart.com.pa/products/368651743-sam-e-400mg-30-enteric-coated-caplets-vegan-kosher-non)

## Best For

- natures trove enthusiasts

## Why This Product

- Trusted natures trove brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Advanced Enteric Coating:** Ensures optimal absorption by protecting caplets from stomach acid, maximizing bioavailability.
- • **Clean & Conscious Formula:** Vegan, kosher, non-GMO, soy and gluten-free—crafted for the mindful professional.
- • **Clinically Potent 400mg Dose:** Delivers a powerful daily boost of SAM-e for mood, joint, and liver support.
- • **Freshness Sealed Blister Pack:** Individually packed caplets maintain peak potency and freshness until the last dose.
- • **Backed by 20+ Years of Expertise:** Formulated by industry pioneers with decades of research and GMP-certified manufacturing.

## Overview

Nature's Trove SAM-e 400mg offers a premium, enteric-coated supplement designed to support mood, joint flexibility, and liver health. Vegan, kosher, and free from common allergens, it delivers the highest active S,S isomer concentration with guaranteed freshness in blister packs. Developed by experts with over 20 years of research, this supplement ensures maximum absorption and bioavailability for the modern wellness-focused professional.

## Description

What is SAMe? SAM-e (S-Adenosyl-Methionine) is a revolutionary dietary supplement that has been successfully used for nearly half a century to support mood and well-being, joint comfort, and healthy liver function. SAM-e is an amino acid that is naturally produced by the body; however, aging, diet, and other factors may cause the levels of SAM-e in one’s body to decline. Nature’s Trove SAM-e is here to help replenish and support beneficial levels of SAM-e in the body. Why choose Nature’s Trove SAMe? The Nature’s Trove team of experts has been working with SAMe for over two decades, and are pioneers in the field. Nature’s Trove SAM-e is a stable, bioavailable form of S-Adenosyl-Methionine, and contains the highest levels of S,S Isomer (active component) available on the market. It is specially manufactured and packaged to maintain optimum potency. The caplets are enteric coated to ensure that they are optimally absorbed by the body for maximum benefit. We are confident that you will enjoy Nature’s Trove SAM-e. As with all Nature’s Trove products, we take great pride in bringing you nature’s greatest treasures at their highest quality. At Nature’s Trove, we believe that natural health should be accessible to all, and by offering our products directly to you, we are achieving this goal, one customer at a time. If you have any comments, suggestions, or questions, please feel free to visit our website or call us at our toll-free number. Recommended dosage: As a dietary supplement, take one caplet daily, preferably on an empty stomach, or as directed by a physician. For some people, additional supplementation may be beneficial. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Review: I enjoy using this product. SAM-e has helped with emotional anxiety for quite awhile.
Review: 🧬 Methionine + ⚡ ATP ➜ 🚀 SAM-e ➜ 🎁 Methyl Donation ➜ 🧪 SAH ➜ ⚠️ Homocysteine ➜ 🔁 (🍃 Folate/5-MTHF + 🧠 B12) ➜ Methionine OR 🔁 (🍬 Betaine/TMG) ➜ Methionine OR 🛡️ (💊 B6) ➜ Cystathionine ➜ Cysteine ➜ 🧤 Glutathione 1) 🧬 Methionine + ⚡ ATP ➜ 🚀 SAM-e Your body takes methionine (an amino acid from food) and uses ATP (cell energy) to create SAM-e. SAM-e = your main “methyl donor fuel.” 2) 🚀 SAM-e ➜ 🎁 Methyl Donation SAM-e’s job is to donate a methyl group (CH₃) to many targets, like: 🧠 neurotransmitter pathways (mood-related chemistry) 🧬 DNA / gene regulation (methylation) 🧈 cell membranes (phospholipids) 🧹 detox/liver processes Think of this step as SAM-e spending its “methyl currency.” 3) After donating ➜ 🧪 SAH Once SAM-e donates, it turns into SAH (S-adenosylhomocysteine). Important: too much SAH can slow methylation (it can block methylation enzymes). 4) 🧪 SAH ➜ ⚠️ Homocysteine SAH is broken down into homocysteine. Homocysteine is a normal intermediate, but if it builds up, it can mean the cycle isn’t recycling efficiently. What happens to homocysteine? (3 main exits) 5A) ⚠️ Homocysteine ➜ 🔁 Methionine (🍃 Folate/5-MTHF + 🧠 B12 route) This is the main recycle path. Active folate (5-MTHF) + B12 help convert homocysteine back into methionine, which can then make more SAM-e. 5B) ⚠️ Homocysteine ➜ 🔁 Methionine (🍬 Betaine/TMG route) This is a backup recycling route (mainly liver/kidney). Betaine (TMG) can donate a methyl group to recycle homocysteine back into methionine. 5C) ⚠️ Homocysteine ➜ 🛡️ (💊 B6 route) ➜ Cystathionine ➜ Cysteine ➜ 🧤 Glutathione This is the antioxidant/cleanup path (“transsulfuration”). With B6, homocysteine can be converted toward cysteine (via cystathionine), which helps make glutathione (a major antioxidant).

## Features

- PREMIUM QUALITY: Nature's Trove is committed to making the highest quality SAM-e supplements affordable for all consumers. We start with raw material that contains the highest level of the active S.S. Isomer, and manufacture it under strictly controlled GMP conditions. The caplets are enteric coated for optimal absorption, and blister packaged for maximum freshness. Our product is free from allergens, artificial coloring and flavors; suitable for vegan, GMO free, and Kosher certified.
- EXPERTISE & INDUSTRY LEADERSHIP: Our experts have been working with SAM-e (s-adenosylmethionine) and perfecting its formulation for over 2 decades. We are pleased to present a product that is backed by an incredible amount of science, literature, and research studies.
- MOOD AND WELLBEING: SAM-e can help promote mood and well-being.
- JOINT HEALTH: SAM-e can help maintain joint flexibility & mobility.
- LIVER HEALTH: SAM-e can support healthy liver functions.

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B071CQ3Y8F |
| ASIN  | B071CQ3Y8F |
| Additives | Gluten Free |
| Age Range Description | Adult |
| Best Sellers Rank | #151,226 in Health ( See Top 100 in Health ) #4,205 in Multiple Vitamin-Mineral Combination Supplements |
| Brand | Natures Trove |
| Customer Reviews | 4.4 4.4 out of 5 stars (1,826) |
| Customer reviews | 4.4 4.4 out of 5 stars (1,826) |
| Date First Available | 26 October 2017 |
| Format | Tablet |
| Is Discontinued By Manufacturer  | No |
| Manufacturer  | Nature's Trove |
| Manufacturer reference  | TRSAM430 |
| Package Dimensions  | 13.49 x 7.9 x 4.7 cm; 59 g |
| Serving Recommendation | 1 caplet |

## Product Details

- **Age range (description):** Adult
- **Brand:** Natures Trove
- **Flavour:** Unflavored
- **Item form:** Tablet
- **Item weight:** 0.13 Pounds
- **Number of Items:** 1
- **Package information:** Blister
- **Product benefits:** Bone & Joint Support
- **Servings per container:** 30.0
- **Special ingredients:** Gluten Free

## Images

![SAM-e 400mg 30 Enteric Coated Caplets. Vegan, Kosher, Non-GMO, Soy Free, Gluten Free - Mood and Joint Support - Cold Form Blister Packed. - Image 1](https://m.media-amazon.com/images/I/71SMlXj6XqL.jpg)

## Questions & Answers

**Q: What is the net yield of sam-e? 400 or 200mg? if 400mg s-adenosylmethionine tosylate disulfate then it is often a net yield of only 200mg-misleading!!**
A: I ordered a bottle of Natures Trove 
Sam-e 400mg.When it arrived the first thing I noticed on the ingredients labeling 
was....SAM-E 400mg from 800mg of Sam-e Tosylate Disulfate... Hmmmm. I have always taken NatureMade Sam-e which states only ( Sam-e( S-adenosylmethionine 400mg. and found it excellent and stable. It has very good enteric coating and is consistent as to when I can feel it effecting my mood and energy. I know it is a reliable brand. 
I am going to give Natures Trove a fair shot as the price is better..... and hope that this difference in labeling of the main ingredient does not mean anything in reference to effectiveness. Does anyone have info to clarify the labeling?

**Q: where is this made?**
A: Hi,
Nature's Trove SAM-e is made in the USA.

**Q: Does this really contain titanium dioxide? (says it "might") that's toxic!!!**
A: The ingredients are on the box and yes titanium dioxide is listed. Whether it is toxic  or not I have no idea. Maybe in the amount that is contained in the product might determine whether it is or not.

**Q: The front cover states its a natural deritive of yeast the back of the box says theres no yeast .I called the 1800 number to ask no answere?**
A: Hi,
SAM-e is derived from a specific natural chemical compound found in yeast however there is no yeast in this product. I hope that answers your question.

## Customer Reviews

### ⭐⭐⭐⭐⭐ Review
*by D***. on 26 February 2026*

I enjoy using this product. SAM-e has helped with emotional anxiety for quite awhile.

### ⭐⭐⭐⭐⭐ Review
*by S***M on 5 January 2026*

🧬 Methionine + ⚡ ATP ➜ 🚀 SAM-e ➜ 🎁 Methyl Donation ➜ 🧪 SAH ➜ ⚠️ Homocysteine ➜ 🔁 (🍃 Folate/5-MTHF + 🧠 B12) ➜ Methionine OR 🔁 (🍬 Betaine/TMG) ➜ Methionine OR 🛡️ (💊 B6) ➜ Cystathionine ➜ Cysteine ➜ 🧤 Glutathione 1) 🧬 Methionine + ⚡ ATP ➜ 🚀 SAM-e Your body takes methionine (an amino acid from food) and uses ATP (cell energy) to create SAM-e. SAM-e = your main “methyl donor fuel.” 2) 🚀 SAM-e ➜ 🎁 Methyl Donation SAM-e’s job is to donate a methyl group (CH₃) to many targets, like: 🧠 neurotransmitter pathways (mood-related chemistry) 🧬 DNA / gene regulation (methylation) 🧈 cell membranes (phospholipids) 🧹 detox/liver processes Think of this step as SAM-e spending its “methyl currency.” 3) After donating ➜ 🧪 SAH Once SAM-e donates, it turns into SAH (S-adenosylhomocysteine). Important: too much SAH can slow methylation (it can block methylation enzymes). 4) 🧪 SAH ➜ ⚠️ Homocysteine SAH is broken down into homocysteine. Homocysteine is a normal intermediate, but if it builds up, it can mean the cycle isn’t recycling efficiently. What happens to homocysteine? (3 main exits) 5A) ⚠️ Homocysteine ➜ 🔁 Methionine (🍃 Folate/5-MTHF + 🧠 B12 route) This is the main recycle path. Active folate (5-MTHF) + B12 help convert homocysteine back into methionine, which can then make more SAM-e. 5B) ⚠️ Homocysteine ➜ 🔁 Methionine (🍬 Betaine/TMG route) This is a backup recycling route (mainly liver/kidney). Betaine (TMG) can donate a methyl group to recycle homocysteine back into methionine. 5C) ⚠️ Homocysteine ➜ 🛡️ (💊 B6 route) ➜ Cystathionine ➜ Cysteine ➜ 🧤 Glutathione This is the antioxidant/cleanup path (“transsulfuration”). With B6, homocysteine can be converted toward cysteine (via cystathionine), which helps make glutathione (a major antioxidant).

### ⭐⭐⭐⭐⭐ Review
*by D***E on 26 February 2026*

Great product!

## Frequently Bought Together

- Nature's Trove SAM-e 400mg 30 Enteric Coated Caplets. Vegan, Kosher, Non-GMO, Soy Free, Gluten Free - Mood and Joint Support - Cold Form Blister Packed.
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*Product available on Desertcart Panama*
*Store origin: PA*
*Last updated: 2026-03-12*