---
product_id: 4114431
title: "FRONTLINE Plus Flea & Tick Spot Treatment for Large Breed Dogs 45-88 lbs. (Purple) Count of 3 | Trusted by pet owners for over 20 years,² kills fleas, ticks & chewing lice, waterproof 24 hr"
brand: "frontline"
price: "B/.135"
currency: PAB
in_stock: true
category: "Frontline"
url: https://www.desertcart.com.pa/products/4114431-frontline-plus-flea-and-tick-spot-treatment-for-large-breed
store_origin: PA
region: Panama
---

# 30-day protection For large breed dogs 45-88 lbs Waterproof 24 hrs FRONTLINE Plus Flea & Tick Spot Treatment for Large Breed Dogs 45-88 lbs. (Purple) Count of 3 | Trusted by pet owners for over 20 years,² kills fleas, ticks & chewing lice, waterproof 24 hr

**Brand:** frontline
**Price:** B/.135
**Availability:** ✅ In Stock

## Summary

> 🐾 Stay ahead of pests with FRONTLINE Plus — because your best friend deserves the best protection!

## Quick Answers

- **What is this?** FRONTLINE Plus Flea & Tick Spot Treatment for Large Breed Dogs 45-88 lbs. (Purple) Count of 3 | Trusted by pet owners for over 20 years,² kills fleas, ticks & chewing lice, waterproof 24 hr by frontline
- **How much does it cost?** B/.135 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.com.pa](https://www.desertcart.com.pa/products/4114431-frontline-plus-flea-and-tick-spot-treatment-for-large-breed)

## Best For

- frontline enthusiasts

## Why This Product

- Trusted frontline brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Trusted Legacy:** Over 20 years of proven reliability trusted by millions of pet owners—join the community that won’t settle for less.
- • **Waterproof Power:** Rain or swim, FRONTLINE Plus stays active 24 hours post-application, ensuring uninterrupted protection.
- • **Month-Long Defense:** One monthly dose shields your dog from fleas, ticks, and chewing lice for a full 30 days—no gaps, no worries.
- • **Effortless Application:** Single-point topical treatment that spreads through sebaceous glands for full-body coverage—easy, fast, and mess-free.
- • **Complete Lifecycle Control:** Kills adult fleas, eggs, larvae, ticks, and chewing lice to break the infestation cycle before it starts.

## Overview

FRONTLINE Plus Flea & Tick Spot Treatment for Large Breed Dogs (45-88 lbs) delivers fast-acting, waterproof protection that kills fleas, ticks, chewing lice, and their eggs for a full 30 days. Trusted by pet owners for over 20 years, this topical treatment uses fipronil and (S)-methoprene to break the flea life cycle and safeguard your dog even after swimming or bathing. Easy to apply and designed for large dogs, it ensures continuous pest control with a single monthly dose.

## Description

Keep your dog protected with the number 1 name in flea & tick protection (1), FRONTLINE. FRONTLINE Plus for Dogs is a fast-acting, long-lasting waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. Break the flea life cycle — FRONTLINE Plus for Dogs is specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control. Trusted by pet owners for over 20 years (2) — FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply. Applied to a single point on your pet, the flea and tick control treatment covers your dog's entire body and deposits in the sebaceous glands. These glands act as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet. Just one dose of FRONTLINE Plus each month protects against fleas & ticks for a full 30 days. FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products. Appropriately treat all pets in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations. Subscribe and save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus. Be sure to visit our brand store and follow us to stay up to date on new FRONTLINE products, features, tips and more. References: (1) BI Marketing Excellence Survey performed by Kynetec, November 2023. (2) 20 years of trust in killing fleas and ticks demonstrated by various studies in the past 20 years including a 2002 Pet Owner Brand Awareness and Attitude Tracking Study performed by Bruno and Ridgway Research Associates and the 2023 BrandSpark© American Trust Study where FRONTLINE Brand Products were voted most trusted for brand for flea & tick prevention.

## Features

- The #1 name in flea and tick protection
- Trusted by pet owners for over 20 years**
- Fast-acting, long-lasting flea and tick treatment thats waterproof 24 hours after application
- Protects from fleas and ticks for a full month
- Kills adult fleas, flea eggs, flea larvae, ticks, and chewing lice
- Aids in the control of sarcoptic mange infestations
- Stops existing flea infestations and prevents establishment of new infestations

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B0002J1FOE |
| ASIN  | B0002J1FOE |
| Active Ingredients | fipronil and (S)-methoprene |
| Age Range Description | All Life Stages |
| Allergen Information | Abalone Free |
| Best Sellers Rank | #256 in Pet Supplies ( See Top 100 in Pet Supplies ) #3 in Dog Flea Drops |
| Brand Name | Frontline |
| Customer Reviews | 4.4 4.4 out of 5 stars (50,504) |
| Date First Available  | September 2, 2004 |
| Department  | Insect Control |
| Dog Breed Size | Large |
| Global Trade Identification Number | 00350604287209 |
| Included Components | Package includes 3 applicators |
| Item Form | Liquid |
| Item Type Name | Topical Purple box |
| Item Weight | 18.14 g |
| Item model number  | 72219 |
| Manufacturer | Boehringer Ingelheim Animal Health |
| Manufacturer  | Boehringer Ingelheim Animal Health |
| Manufacturer Part Number | P004FLTSP-45-88 |
| Model Number | 72219 |
| Product Dimensions  | 5.75 x 0.75 x 4.5 inches; 0.64 ounces |
| Scent Name | Unscented |
| Target Species | Dog |
| UPC | 350604287209 666672366389 |
| Unit Count | 1 Count |
| Volume | 339 ml |
| Warranty Description | only for dog |

## Product Details

- **Active Ingredients:** fipronil and (S)-methoprene
- **Age Range (Description):** All Life Stages
- **Allergen Information:** Abalone Free
- **Brand:** Frontline
- **Dog Breed Size:** Large
- **Item Form:** Liquid
- **Item Volume:** 339 ml
- **Item Weight:** 18.14 g
- **Scent:** Unscented
- **Unit Count:** 1 Count

## Images

![FRONTLINE Plus Flea & Tick Spot Treatment for Large Breed Dogs 45-88 lbs. (Purple) Count of 3 | Trusted by pet owners for over 20 years,² kills fleas, ticks & chewing lice, waterproof 24 hr - Image 1](https://m.media-amazon.com/images/I/71cWyt6fBNL.jpg)

## Available Options

This product comes in different **Size** options.

## Questions & Answers

**Q: I've been using Frontline Plus for years, but lately it seems to be not as effective as it used to be. Has anyone noticed the same results ?**
A: Yes! After trying multiple flea & tick medication, my dog wasn’t getting any better...took her to the vet & she stated that the over the counter flea & tick medication isn’t effective since it’s been on the market for some time, the fleas have evolved & aren’t responding to the meds. Plus she said this season has been the worst so that doesn’t help either!!! Take them to the vet, my dog now is flea/tick free

**Q: "hola buenas tardes, compre este producto pero no veo o no sale la fecha de caducidad ( vencimiento ) del producto "**
A: Siempre que lo mantenga a temperatura ambiente y sellado en su empaque original, FRONTLINE Plus permanecerá listo para la batalla!

**Q: Can I give her a bath**
A: "It is OK to bathe your pet before using FRONTLINE, but the coat should be completely dry prior to application. In the 48 hours immediately after treatment, do not bathe, shampoo or let your dog go swimming." (FRONTLINE webste)
   This medication works systemically after being absorbed through the skin. Insufficient dosing will lead to product failure.

**Q: effectiveness**
A: Ive never had a flea problem with frontline, but for ticks they would attach to the dog before it died. 
So i switched to the seresto 8 month collar. The 1st one i used worked great no issues. The 2nd one 
(8months later) had the same date as the first one. I dont know if that was an issue but the collar stopped working 
after 5 months and we ended up with fleas. First time that we ever had fleas. So i am going back to frontline. 
My concerns are the date on package and where its coming from.

## Frequently Bought Together

- Frontline Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments
- Frontline Plus Flea and Tick Treatment for Small Dogs Upto 5 to 22 lbs. 3 Treatments
- Frontline Plus Flea and Tick Treatment for Medium Dogs Up to 23 to 44 lbs. 3 Treatments

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*Product available on Desertcart Panama*
*Store origin: PA*
*Last updated: 2026-07-30*