---
product_id: 4114431
title: "Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments"
brand: "frontline"
price: "B/.132"
currency: PAB
in_stock: true
reviews_count: 8
category: "Frontline"
url: https://www.desertcart.com.pa/products/4114431-plus-flea-and-tick-treatment-for-large-dogs-up-to
store_origin: PA
region: Panama
---

# 30-day continuous protection Waterproof formula Kills fleas, eggs, larvae & ticks Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments

**Brand:** frontline
**Price:** B/.132
**Availability:** ✅ In Stock

## Summary

> 🐾 Stay ahead of pests with FRONTLINE Plus — because your dog’s comfort is non-negotiable!

## Quick Answers

- **What is this?** Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments by frontline
- **How much does it cost?** B/.132 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.com.pa](https://www.desertcart.com.pa/products/4114431-plus-flea-and-tick-treatment-for-large-dogs-up-to)

## Best For

- frontline enthusiasts

## Why This Product

- Trusted frontline brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Month-Long Defense:** One monthly dose shields your dog from fleas & ticks for a full 30 days, so you never miss a beat.
- • **Waterproof & Active:** Water-resistant formula stays effective even after your dog’s outdoor adventures or bath time.
- • **Trusted for 20+ Years:** Backed by decades of proven reliability and pet owner trust, because your dog deserves the best.
- • **Complete Life Cycle Kill:** Targets adult fleas, eggs, larvae, and ticks—including those that carry Lyme disease—for total pest control.
- • **Easy Application, Full Coverage:** Single-point topical treatment spreads through sebaceous glands, protecting your dog’s entire body effortlessly.

## Overview

FRONTLINE Plus Flea and Tick Treatment for Large Dogs (45-88 lbs) delivers fast-acting, waterproof protection that kills fleas, flea eggs, larvae, chewing lice, and ticks for a full 30 days. Formulated with fipronil and (S)-methoprene, it breaks the flea life cycle and guards against Lyme disease-carrying ticks. Trusted by pet owners for over 20 years, this easy-to-apply topical treatment continuously replenishes through sebaceous glands, ensuring reliable, all-over protection even if your dog gets wet.

## Description

Keep your dog protected with the number 1 name in flea & tick protection (1), FRONTLINE. FRONTLINE Plus for Dogs is a fast-acting, long-lasting waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. Break the flea life cycle — FRONTLINE Plus for Dogs is specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control. Trusted by pet owners for over 20 years (2) — FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply. Applied to a single point on your pet, the flea and tick control treatment covers your dog's entire body and deposits in the sebaceous glands. These glands act as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet. Just one dose of FRONTLINE Plus each month protects against fleas & ticks for a full 30 days. FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products. Appropriately treat all pets in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations. Subscribe and save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus. Be sure to visit our brand store and follow us to stay up to date on new FRONTLINE products, features, tips and more. References: (1) BI Marketing Excellence Survey performed by Kynetec, November 2023. (2) 20 years of trust in killing fleas and ticks demonstrated by various studies in the past 20 years including a 2002 Pet Owner Brand Awareness and Attitude Tracking Study performed by Bruno and Ridgway Research Associates and the 2023 BrandSpark© American Trust Study where FRONTLINE Brand Products were voted most trusted for brand for flea & tick prevention.

Review: Keeps the fleas away - Frontline works great no fleas on my dog. I have been using this brand for years
Review: Works perfectly! - ⭐️⭐️⭐️⭐️⭐️ Works perfectly! FRONTLINE Plus worked perfectly for my dog. It keeps him safe from fleas and ticks, even though he loves running around the yard. Very reliable and effective!

## Features

- Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
- Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
- Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
- FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
- Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations
- Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus

## Technical Specifications

| Specification | Value |
|---------------|-------|
| Active Ingredients | fipronil and (S)-methoprene |
| Brand | Frontline |
| Customer Reviews | 4.4 out of 5 stars 49,416 Reviews |
| Item Form | Liquid |
| Item Volume | 339 Milliliters |
| Item Weight | 0.04 Pounds |
| Scent | Unscented |

## Product Details

- **Active Ingredients:** fipronil and (S)-methoprene
- **Age Range (Description):** All Life Stages
- **Allergen Information:** Abalone Free
- **Brand:** Frontline
- **Dog Breed Size:** Large
- **Item Form:** Liquid
- **Item Volume:** 339 Milliliters
- **Item Weight:** 0.04 Pounds
- **Scent:** Unscented
- **UPC:** 350604287209 666672366389

## Images

![Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments - Image 1](https://m.media-amazon.com/images/I/71cWyt6fBNL.jpg)

## Available Options

This product comes in different **Size** options.

## Questions & Answers

**Q: I've been using Frontline Plus for years, but lately it seems to be not as effective as it used to be. Has anyone noticed the same results ?**
A: Yes! After trying multiple flea & tick medication, my dog wasn’t getting any better...took her to the vet & she stated that the over the counter flea & tick medication isn’t effective since it’s been on the market for some time, the fleas have evolved & aren’t responding to the meds. Plus she said this season has been the worst so that doesn’t help either!!! Take them to the vet, my dog now is flea/tick free

**Q: "hola buenas tardes, compre este producto pero no veo o no sale la fecha de caducidad ( vencimiento ) del producto "**
A: Siempre que lo mantenga a temperatura ambiente y sellado en su empaque original, FRONTLINE Plus permanecerá listo para la batalla!

**Q: Can I give her a bath**
A: "It is OK to bathe your pet before using FRONTLINE, but the coat should be completely dry prior to application. In the 48 hours immediately after treatment, do not bathe, shampoo or let your dog go swimming." (FRONTLINE webste)
   This medication works systemically after being absorbed through the skin. Insufficient dosing will lead to product failure.

**Q: effectiveness**
A: Ive never had a flea problem with frontline, but for ticks they would attach to the dog before it died. 
So i switched to the seresto 8 month collar. The 1st one i used worked great no issues. The 2nd one 
(8months later) had the same date as the first one. I dont know if that was an issue but the collar stopped working 
after 5 months and we ended up with fleas. First time that we ever had fleas. So i am going back to frontline. 
My concerns are the date on package and where its coming from.

## Customer Reviews

### ⭐⭐⭐⭐⭐ Keeps the fleas away
*by V***S on December 27, 2025*

Frontline works great no fleas on my dog. I have been using this brand for years

### ⭐⭐⭐⭐⭐ Works perfectly!
*by J***I on December 23, 2025*

⭐️⭐️⭐️⭐️⭐️ Works perfectly! FRONTLINE Plus worked perfectly for my dog. It keeps him safe from fleas and ticks, even though he loves running around the yard. Very reliable and effective!

### ⭐⭐⭐⭐⭐ I like
*by K***P on January 17, 2026*

It's definitely something I would buy again. It comes with three applications, and you can use it once a month, so it provides coverage for 3 months.

## Frequently Bought Together

- Frontline Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments
- Frontline Plus Flea and Tick Treatment for Small Dogs Upto 5 to 22 lbs. 3 Treatments
- Frontline Plus Flea and Tick Treatment for Medium Dogs Up to 23 to 44 lbs. 3 Treatments

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*Product available on Desertcart Panama*
*Store origin: PA*
*Last updated: 2026-02-06*